70
70
Oct 28, 2014
10/14
by
Emori, Makoto; Tsukahara, Tomohide; Murase, Masaki; Kano, Masanobu; Murata, Kenji; Takahashi, Akari; Kubo, Terufumi; Asanuma, Hiroko; Yasuda, Kazuyo; Kochin, Vitaly; Kaya, Mitsunori; Nagoya, Satoshi; Nishio, Jun; Iwasaki, Hiroshi; Sonoda, Tomoko; Hasegawa, Tadashi; Torigoe, Toshihiko; Wada, Takuro; Yamashita, Toshihiko; Sato, Noriyuki
texts
eye 70
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Epithelioid sarcoma (ES) is a relatively rare, highly malignant soft tissue sarcoma. The mainstay of treatment is resection or amputation. Currently other therapeutic options available for this disease are limited. Therefore, a novel therapeutic option needs to be developed. In the present study, we established a new human ES cell line (ESX) and analyzed the characteristics of its cancer stem-like cells/cancer-initiating cells (CSCs/CICs)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869840
41
41
Oct 25, 2014
10/14
by
Kraemer, Anne; Chen, I-Peng; Henning, Stefan; Faust, Alexandra; Volkmer, Beate; Atkinson, Michael J.; Moertl, Simone; Greinert, Ruediger
texts
eye 41
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract MicroRNA (miRNA)-mediated regulation of the cellular transcriptome is an important epigenetic mechanism for fine-tuning regulatory pathways. These include processes related to skin cancer development, progression and metastasis. However, little is known about the role of microRNA as an intermediary in the carcinogenic processes following exposure to UV-radiation. We now show that UV irradiation of human primary keratinocytes modulates the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877020
24
24
Oct 24, 2014
10/14
by
Rasmussen, Claus; Dupont, Yoko L.; Mosbacher, Jesper B.; Tr?jelsgaard, Kristian; Olesen, Jens M.
texts
eye 24
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Most ecological networks are analysed as static structures, where all observed species and links are present simultaneously. However, this is over-simplified, because networks are temporally dynamical. We resolved an arctic, entire-season plant-flower visitor network into a temporal series of 1-day networks and compared the properties with its static equivalent based on data pooled over the entire season. Several properties differed. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852737
44
44
Oct 28, 2014
10/14
by
Yellon, Steven M.; Dobyns, Abigail E.; Beck, Hailey L.; Kurtzman, James T.; Garfield, Robert E.; Kirby, Michael A.
texts
eye 44
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the focus of the present study. Groups of pregnant rats were treated with vehicle, a progesterone receptor antagonist (onapristone or mifepristone), or ovariectomized on day 17 postbreeding. As...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858221
44
44
Oct 28, 2014
10/14
by
Mesquita, Rickson C.; D'Souza, Angela; Bilfinger, Thomas V.; Galler, Robert M.; Emanuel, Asher; Schenkel, Steven S.; Yodh, Arjun G.; Floyd, Thomas F.
texts
eye 44
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Spinal cord ischemia can lead to paralysis or paraparesis, but if detected early it may be amenable to treatment. Current methods use evoked potentials for detection of spinal cord ischemia, a decades old technology whose warning signs are indirect and significantly delayed from the onset of ischemia. Here we introduce and demonstrate a prototype fiber optic device that directly measures spinal cord blood flow and oxygenation. This technical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865183
28
28
Oct 24, 2014
10/14
by
Saenz, Shirley; Walschburger, Tomas; Gonzalez, Juan Carlos; Leon, Jorge; McKenney, Bruce; Kiesecker, Joseph
texts
eye 28
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Mitigation policy and regulatory frameworks are consistent in their strong support for the mitigation hierarchy of: (1) avoiding impacts, (2) minimizing impacts, and then (3) offsetting/compensating for residual impacts. While mitigation frameworks require developers to avoid, minimize and restore biodiversity on-site before considering an offset for residual impacts, there is a lack of quantitative guidance for this decision-making process....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855343
43
43
Oct 27, 2014
10/14
by
Larsen, Michael Due; Hallas, Jesper
texts
eye 43
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: The aim of this study was to describe the use of gastrointestinal (GI) protection before, during and after hospitalisation for elderly patients using NSAID or low-dose ASA. Methods: This study included all elderly patients (75+) admitted to hospital in the period of 1st April 2010 to 31st March 2011 at Odense University Hospital, Denmark, who were regular users of NSAID or low-dose ASA before hospital admission, or had one of these...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857789
48
48
Oct 27, 2014
10/14
by
Li, Shufeng; Tian, Liang; Han, Zhao; Wang, Jing
texts
eye 48
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: The necessity of postural restriction to patients suffering from benign paroxysmal positional vertigo is controversial. Objective: To investigate the impact of the sleep position after the repositioning maneuver on BPPV recurrence. Methods: 150 unilateral BPPV patients who were treated by repositioning maneuver were distributed into two groups. The patients in group A were instructed to sleep in a semi-sitting position at an angle...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867465
35
35
Oct 26, 2014
10/14
by
Klein, Cecilia C.; Alves, Joao M. P.; Serrano, Myrna G.; Buck, Gregory A.; Vasconcelos, Ana Tereza R.; Sagot, Marie-France; Teixeira, Marta M. G.; Camargo, Erney P.; Motta, Maria Cristina M.
texts
eye 35
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Some non-pathogenic trypanosomatids maintain a mutualistic relationship with a betaproteobacterium of the Alcaligenaceae family. Intensive nutritional exchanges have been reported between the two partners, indicating that these protozoa are excellent biological models to study metabolic co-evolution. We previously sequenced and herein investigate the entire genomes of five trypanosomatids which harbor a symbiotic bacterium (SHTs for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833962
26
26
Oct 24, 2014
10/14
by
Masuda, Naoki; Kurahashi, Issei; Onari, Hiroko
texts
eye 26
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract : Suicide explains the largest number of death tolls among Japanese adolescents in their twenties and thirties. Suicide is also a major cause of death for adolescents in many other countries. Although social isolation has been implicated to influence the tendency to suicidal behavior, the impact of social isolation on suicide in the context of explicit social networks of individuals is scarcely explored. To address this question, we examined a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637384
33
33
Oct 27, 2014
10/14
by
Hofmann, Mareike; Kohler, Birgit; Leichsenring, Falk; Kruse, Johannes
texts
eye 33
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Objective: To quantify the impact of depression measured by self-reports and depression measured by clinical interview on all-cause mortality in individuals with diabetes and to analyze the strength of both associations, the influence of covariates, and possible differences between studies assessing self-rated depressive symptoms and those using a clinical interview to measure depression as predictors of mortality. Research Design and Methods:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836777
23
23
Oct 26, 2014
10/14
by
Gee, Fiona; Fisher, Kate; Klemstein, Ulrike; Poulin, Gino B.
texts
eye 23
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Attenuation of RAS/RAF/MAPK signalling is essential to prevent hyperactivation of this oncogenic pathway. In C. elegans, the sumoylation pathway and a combination of histone tail modifications regulate gene expression to attenuate the LET-60 (RAS) signalling pathway. We hypothesised that a number of chromatin regulators are likely to depend on sumoylation to attenuate the pathway. To reveal these, we designed an RNAi-based dimorphic genetic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862036
25
25
Oct 29, 2014
10/14
by
Rowe, Suzanne J.; Rowlatt, Amy; Davies, Gail; Harris, Sarah E.; Porteous, David J.; Liewald, David C.; McNeill, Geraldine; Starr, John M.; Deary, Ian J.; Tenesa, Albert
texts
eye 25
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Combining information from multiple SNPs may capture a greater amount of genetic variation than from the sum of individual SNP effects and help identifying missing heritability. Regions may capture variation from multiple common variants of small effect, multiple rare variants or a combination of both. We describe regional heritability mapping of human cognition. Measures of crystallised (gc) and fluid intelligence (gf) in late adulthood...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865348
28
28
Oct 25, 2014
10/14
by
Tanahashi, Takao; Yamamoto, Tomohisa; Endo, Takuyuki; Fujimura, Harutoshi; Yokoe, Masaru; Mochizuki, Hideki; Nomura, Taishin; Sakoda, Saburo
texts
eye 28
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Freezing of gait in patients with Parkinson’s disease is associated with several factors, including interlimb incoordination and impaired gait cycle regulation. Gait analysis in patients with Parkinson’s disease is confounded by parkinsonian symptoms such as rigidity. To understand the mechanisms underlying freezing of gait, we compared gait patterns during straight walking between 9 patients with freezing of gait but little to no...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877290
30
30
Oct 28, 2014
10/14
by
Wang, Zhuo; Myers, Kalisa G.; Guo, Yumei; Ocampo, Marco A.; Pang, Raina D.; Jakowec, Michael W.; Holschneider, Daniel P.
texts
eye 30
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Exercise training is widely used for neurorehabilitation of Parkinson’s disease (PD). However, little is known about the functional reorganization of the injured brain after long-term aerobic exercise. We examined the effects of 4 weeks of forced running wheel exercise in a rat model of dopaminergic deafferentation (bilateral, dorsal striatal 6-hydroxydopamine lesions). One week after training, cerebral perfusion was mapped during treadmill...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836982
26
26
Oct 24, 2014
10/14
by
Lagarde, Julien; Valabregue, Romain; Corvol, Jean-Christophe; Pineau, Fanny; Le Ber, Isabelle; Vidailhet, Marie; Dubois, Bruno; Levy, Richard
texts
eye 26
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTD) are two clinicohistological entities that share a severe prefrontal syndrome. To what extent do the cognitive syndrome and the location of the underlying brain atrophy unify or segregate these entities? Here, we examined the clinical and radiological patterns of frontal involvement and the neural bases of the cognitive dysfunctions observed in the Richardson form...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835584
29
29
Oct 28, 2014
10/14
by
Chu, Ying-Hua; Lin, Fa-Hsuan; Chou, Yu-Jen; Tsai, Kevin W.-K.; Kuo, Wen-Jui; Jaaskelainen, Iiro P.
texts
eye 29
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Seeing the articulatory gestures of the speaker (“speech reading”) enhances speech perception especially in noisy conditions. Recent neuroimaging studies tentatively suggest that speech reading activates speech motor system, which then influences superior-posterior temporal lobe auditory areas via an efference copy. Here, nineteen healthy volunteers were presented with silent videoclips of a person articulating Finnish vowels /a/, /i/...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837007
27
27
Oct 24, 2014
10/14
by
Kopeikina, Katherine J.; Wegmann, Susanne; Pitstick, Rose; Carlson, George A.; Bacskai, Brian J.; Betensky, Rebecca A.; Hyman, Bradley T.; Spires-Jones, Tara L.
texts
eye 27
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer’s disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium homeostasis, synapse loss and pathological changes in tau. Here we test the hypothesis that pathological changes in tau are associated with changes...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835324
23
23
Oct 29, 2014
10/14
by
Pereira-Carvalho, Regina; Mendes-Aguiar, Carolina O.; Oliveira-Neto, Manoel P.; Covas, Claudia J. F.; Bertho, Alvaro L.; Da-Cruz, Alda M.; Gomes-Silva, Adriano
texts
eye 23
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Leishmania (Viannia) braziliensis control and tissue damage relate to the effector immune response, which in turn affects clinical outcome. Leishmania reactive CD4+ and CD8+ T cells are expanded in long-term healed cutaneous leishmaniasis (hCL) patients but their functional characteristics remain to be determined. This study investigates antigen-specific recall in long-term healed CL caused by L. braziliensis infection. Healed CL subjects...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841203
34
34
Oct 28, 2014
10/14
by
Guo, Haiyan; King, Megan C.
texts
eye 34
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Eukaryotic organisms employ a variety of mechanisms during meiosis to assess and ensure the quality of their gametes. Defects or delays in successful meiotic recombination activate conserved mechanisms to delay the meiotic divisions, but many multicellular eukaryotes also induce cell death programs to eliminate gametes deemed to have failed during meiosis. It is generally thought that yeasts lack such mechanisms. Here, we show that in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846778
34
34
Oct 28, 2014
10/14
by
Nielsen, Tue Kjaergaard; Xu, Zhuofei; Gozdereliler, Erkin; Aamand, Jens; Hansen, Lars Hestbjerg; S?rensen, Sebastian R.
texts
eye 34
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The 2-methyl-4-chlorophenoxyacetic (MCPA) acid-degrader Sphingomonas sp. ERG5 has recently been isolated from MCPA-degrading bacterial communities. Using Illumina-sequencing, the 5.7 Mb genome of this isolate was sequenced in this study, revealing the 138 kbp plasmid pCADAB1 harboring the 32.5 kbp composite transposon Tn6228 which contains genes encoding proteins for the removal of 2,4-dichlorophenoxyacetic acid (2,4-D) and MCPA, as well as...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877037
41
41
Oct 29, 2014
10/14
by
Yamanaka, Toshiaki; Fukuda, Takehiko; Shirota, Shiho; Sawai, Yachiyo; Murai, Takayuki; Fujita, Nobuya; Hosoi, Hiroshi
texts
eye 41
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Objectives/Hypothesis: Metabolic syndrome (MetS) is a condition that increases the risk of coronary artery disease and cerebral infarction. We determined the prevalence of MetS in vertigo patients and clinically investigated the association between MetS and vertigo. Study Design: Case-control study Methods: The subjects were 333 patients, including 107 males and 226 females, who presented with vertigo as a primary symptom. MetS was diagnosed...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848922
53
53
Oct 27, 2014
10/14
by
Ouyang, Ping; Arif, Mohammad; Fletcher, Jacqueline; Melcher, Ulrich; Ochoa Corona, Francisco Manuel
texts
eye 53
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract A reliable, accurate and rapid multigene-based assay combining real time quantitative PCR (qPCR) and a Razor Ex BioDetection System (Razor Ex) was validated for detection of Xylella fastidiosa subsp. pauca (Xfp, a xylem-limited bacterium that causes citrus variegated chlorosis [CVC]). CVC, which is exotic to the United States, has spread through South and Central America and could significantly impact U.S. citrus if it arrives. A method for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843690
22
22
Oct 24, 2014
10/14
by
Lu, Junchang; Yi, Laiping; Zhong, Hui; Wei, Xuefang
texts
eye 22
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract A new oviraptorosaur Nankangia jiangxiensis gen. et sp. nov. is described on the basis of a partial postcranial skeleton with a partial lower jaw collected from the Upper Cretaceous Nanxiong Formation of Ganzhou, in Jiangxi Province of southern China. The new taxon is diagnosed by: (1) a mandibular symphysis that is not turned down; (2) neural spines of the cranial caudal vertebrae that are wider transversely than anteroposteriorly, forming a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842309
24
24
Oct 27, 2014
10/14
by
Mosley, Jonathan D.; Van Driest, Sara L.; Larkin, Emma K.; Weeke, Peter E.; Witte, John S.; Wells, Quinn S.; Karnes, Jason H.; Guo, Yan; Bastarache, Lisa; Olson, Lana M.; McCarty, Catherine A.; Pacheco, Jennifer A.; Jarvik, Gail P.; Carrell, David S.; Larson, Eric B.; Crosslin, David R.; Kullo, Iftikhar J.; Tromp, Gerard; Kuivaniemi, Helena; Carey, David J.; Ritchie, Marylyn D.; Denny, Josh C.; Roden, Dan M.
texts
eye 24
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract A single mutation can alter cellular and global homeostatic mechanisms and give rise to multiple clinical diseases. We hypothesized that these disease mechanisms could be identified using low minor allele frequency (MAF
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861317
40
40
Oct 28, 2014
10/14
by
Xu, Yan; Guo, Wan-jun; Wang, Qiang; Lanzi, Gongga; Luobu, Ouzhu; Ma, Xiao-hong; Wang, Ying-cheng; Zhen, Puo; Deng, Wei; Liu, Xiang; Zhuoma, Basang; Liu, Xie-he; Li, Tao; Hu, Xun
texts
eye 40
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Studies of linkage and association in various ethnic populations have revealed many predisposing genes of multiple neurotransmitter systems for alcohol use disorders (AUD). However, evidence often is contradictory regarding the contribution of most candidate genes to the susceptibility of AUD. We, therefore, performed a case-control study to investigate the possible associations of genes selected from multiple neurotransmitter systems with AUD...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842251
37
37
Oct 25, 2014
10/14
by
Xiong, Kunlin; Zhang, Ye; Qiu, Mingguo; Zhang, Jingna; Sang, Linqiong; Wang, Li; Xie, Bing; Wang, Jian; Li, Min
texts
eye 37
favorite 1
comment 0
This article is from PLoS ONE , volume 8 . Abstract Objective: To explore the neural mechanisms of negative emotion regulation in patients with post-traumatic stress disorder (PTSD). Methods: Twenty PTSD patients and 20 healthy subjects were recruited. Event-related functional magnetic resonance imaging (fMRI) was used to investigate the modification of emotional responses to negative stimuli. Participants were required to regulate their emotional reactions according to the auditory regulation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862486
32
32
Oct 24, 2014
10/14
by
Ohs, Inga; Windmann, Sonja; Wildner, Oliver; Dittmer, Ulf; Bayer, Wibke
texts
eye 32
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Interleukins (IL) are cytokines with stimulatory and modulatory functions in the immune system. In this study, we have chosen interleukins which are involved in the enhancement of TH2 responses and B cell functions to analyze their potential to improve a prophylactic adenovirus-based anti-retroviral vaccine with regard to antibody and virus-specific CD4+ T cell responses. Mice were vaccinated with an adenoviral vector which encodes and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857891
40
40
Oct 28, 2014
10/14
by
Juurlink, David N.; Dormuth, Colin R.; Huang, Anjie; Hellings, Chelsea; Paterson, J. Michael; Raymond, Colette; Kozyrskyj, Anita; Moride, Yola; Macdonald, Erin M.; Mamdani, Muhammad M.
texts
eye 40
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: Recent evidence suggests that proton pump inhibitors (PPIs) might be linked with adverse cardiac events, but a causal relationship is unproven. Methods: We applied the self-matched case series method to two studies using population-based health care data from Ontario, Canada between 1996 and 2008. The first included subjects aged 66 years or older hospitalized for acute myocardial infarction within 12 weeks following initiation of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873988
22
22
Oct 25, 2014
10/14
by
Elfaitouri, Amal; Herrmann, Bjorn; Bolin-Wiener, Agnes; Wang, Yilin; Gottfries, Carl-Gerhard; Zachrisson, Olof; Pipkorn, R?diger; Ronnblom, Lars; Blomberg, Jonas
texts
eye 22
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Myalgic encephalomyelitis (ME, also called Chronic Fatigue Syndrome), a common disease with chronic fatigability, cognitive dysfunction and myalgia of unknown etiology, often starts with an infection. The chaperonin human heat shock protein 60 (HSP60) occurs in mitochondria and in bacteria, is highly conserved, antigenic and a major autoantigen. The anti-HSP60 humoral (IgG and IgM) immune response was studied in 69 ME patients and 76 blood...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842916
28
28
Oct 26, 2014
10/14
by
Yuan, Wu-Jie; Zhou, Jian-Fang; Zhou, Changsong
texts
eye 28
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract In sensory neural system, external asynchronous stimuli play an important role in perceptual learning, associative memory and map development. However, the organization of structure and dynamics of neural networks induced by external asynchronous stimuli are not well understood. Spike-timing-dependent plasticity (STDP) is a typical synaptic plasticity that has been extensively found in the sensory systems and that has received much theoretical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877323
23
23
Oct 27, 2014
10/14
by
Tiburzy, Benjamin; Szyska, Martin; Iwata, Hiroaki; Chrobok, Navina; Kulkarni, Upasana; Hirose, Misa; Ludwig, Ralf J.; Kalies, Kathrin; Westermann, Jurgen; Wong, David; Manz, Rudolf Armin
texts
eye 23
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Autoantibodies are believed to be maintained by either the continuous generation of short-lived plasma cells in secondary lymphoid tissues or by long-lived plasma cells localized in bone marrow and spleen. Here, we show in a mouse model for the autoimmune blistering skin disease epidermolysis bullosa acquisita (EBA) that chronic autoantibody production can also be maintained in inflamed lymph nodes, by plasma cells exhibiting intermediate...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873383
23
23
Oct 26, 2014
10/14
by
Abranches, Elsa; Bekman, Evguenia; Henrique, Domingos
texts
eye 23
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: The pluripotent state in embryonic stem (ES) cells is controlled by a core network of transcription factors that includes Nanog, Oct4 and Sox2. Nanog is required to reach pluripotency during somatic reprogramming and is the only core factor whose overexpression is able to oppose differentiation-promoting signals. Additionally, Nanog expression is known to fluctuate in ES cells, and different levels of Nanog seem to correlate with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602340
41
41
Oct 25, 2014
10/14
by
Belfiori, Beatrice; Riccioni, Claudia; Paolocci, Francesco; Rubini, Andrea
texts
eye 41
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Tuber spp. are filamentous ascomycetes which establish symbiosis with the roots of trees and shrub species. By virtue of this symbiosis they produce hypogeous ascocarps, known as truffles. Filamentous ascomycetes can reproduce by homothallism or heterothallism depending on the structure and organization of their mating type locus. The first mating type locus in a truffle species has been recently characterized in Tuber melanosporum and it has...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864998
29
29
Oct 28, 2014
10/14
by
Suarez-Farinas, Mayte; Arbeit, Robert; Jiang, Weiwen; Ortenzio, Francesca S.; Sullivan, Tim; Krueger, James G.
texts
eye 29
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR antagonists on the gene expression profile in an IL-23-induced skin inflammation model in mice. Psoriasis-like skin lesions were induced in C57BL/6...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874038
59
59
Oct 28, 2014
10/14
by
Wilkinson, Clare; Weitkamp, Emma
texts
eye 59
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract In the face of demands for researchers to engage more actively with a wider range of publics and to capture different kinds of research impacts and engagements, we explored the ways a small number of environmental researchers use traditional and social media to disseminate research. A questionnaire was developed to investigate the impact of different media as a tool to broker contact between researchers and a variety of different stakeholders...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862833
34
34
Oct 25, 2014
10/14
by
Varasteh, Zohreh; Aberg, Ola; Velikyan, Irina; Lindeberg, Gunnar; Sorensen, Jens; Larhed, Mats; Antoni, Gunnar; Sandstrom, Mattias; Tolmachev, Vladimir; Orlova, Anna
texts
eye 34
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this receptor can be used as a potential molecular target to visualize and treat these tumors. We have previously investigated an antagonist analog of bombesin (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2, RM26) conjugated to 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) via a diethylene glycol (PEG2) spacer (NOTA-P2-RM26) labeled with 68Ga and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849266
22
22
Oct 25, 2014
10/14
by
Sfara, Valeria; Mougabure-Cueto, Gaston A.; Zerba, Eduardo N.; Alzogaray, Raul A.
texts
eye 22
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract N,N-diethyl-3-methylbenzamide (DEET) is the active principle of most insect repellents used worldwide. However, its toxicity on insects has not been widely studied. The aim of this work is to study the effects of DEET on the locomotor activity of Blattella germanica. DEET has a dose-dependent repellent activity on B. germanica. Locomotor activity was significantly lower when insects were pre-exposed to 700 µg/cm2 of DEET for 20 or 30 minutes,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871674
25
25
Oct 24, 2014
10/14
by
Miyagawa, Yosuke; Ogawa, Jun; Iwata, Yuji; Koizumi, Nozomu; Mishiba, Kei-ichiro
texts
eye 25
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Although tremendous progress has been made in recent years in identifying molecular mechanisms of small interfering RNA (siRNA) functions in higher plants, the possibility of direct interaction between genomic DNA and siRNA remains an enigma. Such an interaction was proposed in the ‘RNA cache’ hypothesis, in which a mutant allele is restored based on template-directed gene conversion. To test this hypothesis, we generated transgenic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837478
30
30
Oct 24, 2014
10/14
by
Breniere, Simone Frederique; Salas, Renata; Buitrago, Rosio; Bremond, Philippe; Sosa, Victor; Bosseno, Marie-France; Waleckx, Etienne; Depickere, Stephanie; Barnabe, Christian
texts
eye 30
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Triatoma infestans, the major vector of Chagas disease south of the Amazon in South America, has a large distribution of wild populations, contrary to what has previously been stated. These populations have been suspected of being the source of reinfestation of human habitats and could impede the full success of vector control campaigns. This study examined gene flow between intra-peridomestic populations and wild populations collected in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835561
31
31
Oct 28, 2014
10/14
by
Karch, Andre; Manthey, Henrike; Ponto, Claudia; Hermann, Peter; Heinemann, Uta; Schmidt, Christian; Zerr, Inga
texts
eye 31
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: Since more than a decade ApoE is known to be a strong risk factor for Alzheimer's disease (AD); however, molecular pathways mediating this risk are still unclear. In recent years it has been hypothesized that ApoE might play a role in the disintegration of blood-brain barrier (BBB). In the present study we addressed the question if ApoE genotypes might be associated with BBB function measured by albumin ratio (QAlb) in a large...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874026
34
34
Oct 26, 2014
10/14
by
Wang, Jun; Hui, Dafeng; Ren, Hai; Liu, Zhanfeng; Yang, Long
texts
eye 34
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Establishing seedlings in subtropical plantations is very important for forest health, succession and management. Information on seedling nutrient concentrations is essential for both the selection of suitable indigenous tree species to accelerate succession of the established plantation and sustainable forest management. In this study, we investigated the concentrations of nitrogen ([N]), phosphorus ([P]), and N∶P ratio in leaves, stems and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873957
25
25
Oct 25, 2014
10/14
by
Sedes, Lauriane; Leclerc, Arnaud; Moindjie, Hadia; Cate, Richard L.; Picard, Jean-Yves; di Clemente, Nathalie; Jamin, Soazik P.
texts
eye 25
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily secreted by the gonads of both sexes. This hormone is primarily known for its role in the regression of the Müllerian ducts in male fetuses. In females, AMH is expressed in granulosa cells of developing follicles. Like other members of the TGF-β superfamily, AMH transduces its signal through two transmembrane serine/threonine kinase receptors including a well characterized...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842941
28
28
Oct 28, 2014
10/14
by
Akasheh, Rand T.; Pini, Maria; Pang, Jingbo; Fantuzzi, Giamila
texts
eye 28
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Production of Annexin A1 (ANXA1), a protein that mediates the anti-inflammatory action of glucocorticoids, is altered in obesity, but its role in modulation of adiposity has not yet been investigated. The objective of this study was to investigate modulation of ANXA1 in adipose tissue in murine models of obesity and to study the involvement of ANXA1 in diet-induced obesity in mice. Significant induction of ANXA1 mRNA was observed in adipose...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846785
30
30
Oct 27, 2014
10/14
by
Falkstedt, Daniel; Sorjonen, Kimmo; Hemmingsson, Tomas; Deary, Ian J.; Melin, Bo
texts
eye 30
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Objective: The possible contributions of psychosocial functioning and intelligence differences to socioeconomic status (SES)-related inequalities in premature death were investigated. None of the previous studies focusing on inequalities in mortality has included measures of both psychosocial functioning and intelligence. Methods: The study was based on a cohort of 49 321 men born 1949–1951 from the general community in Sweden. Data on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859588
26
26
Oct 29, 2014
10/14
by
Sosa-Montes De Oca, Claudia; Martinez-Ruiz, Francisca; Rodriguez-Tovar, Francisco Javier
texts
eye 26
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract An ultra-high-resolution analysis of major and trace element contents from the Cretaceous–Paleogene boundary interval in the Caravaca section, southeast Spain, reveals a quick recovery of depositional conditions after the impact event. Enrichment/depletion profiles of redox sensitive elements indicate significant geochemical anomalies just within the boundary ejecta layer, supporting an instantaneous recovery –some 102 years– of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862577
24
24
Oct 29, 2014
10/14
by
Nomachi, Akira; Yoshinaga, Masanori; Liu, Jaron; Kanchanawong, Pakorn; Tohyama, Kiyoshi; Thumkeo, Dean; Watanabe, Takeshi; Narumiya, Shuh; Hirata, Takako
texts
eye 24
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract The lipid mediator sphingosine 1-phosphate (S1P) regulates a wide range of cellular activities, including vascular maturation, angiogenesis, and immune-cell trafficking. Among the five known receptors for S1P (S1PR1-S1PR5), S1PR1 is a critical regulator of lymphocyte trafficking: its signaling is required for lymphocyte egress from lymphoid organs, while its down-modulation by agonist-induced internalization is a prerequisite for lymphocyte...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865155
25
25
Oct 24, 2014
10/14
by
Yuan, Kai; Farney, Jaymelynn K.; Mamedova, Laman K.; Sordillo, Lorraine M.; Bradford, Barry J.
texts
eye 25
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Inflammation may be a major contributing factor to peripartum metabolic disorders in dairy cattle. We tested whether administering an inflammatory cytokine, recombinant bovine tumor necrosis factor-α (rbTNFα), affects milk production, metabolism, and health during this period. Thirty-three Holstein cows (9 primiparous and 24 multiparous) were randomly assigned to 1 of 3 treatments at parturition. Treatments were 0 (Control), 1.5, or 3.0...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833956
27
27
Oct 24, 2014
10/14
by
Millman, Alexander J.; Dowdy, David W.; Miller, Cecily R.; Brownell, Robert; Metcalfe, John Z.; Cattamanchi, Adithya; Davis, J. Lucian
texts
eye 27
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Background: Respiratory isolation of inpatients during evaluation for TB is a slow and costly process in low-burden settings. Xpert MTB/RIF (Xpert) is a novel molecular test for tuberculosis (TB) that is faster and more sensitive but substantially more expensive than smear microscopy. No previous studies have examined the costs of molecular testing as a replacement for smear microscopy in this setting. Methods: We conducted an incremental...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835836
36
36
Oct 26, 2014
10/14
by
Gong, Jianfeng; Zhu, Lijing; Guo, Zhen; Li, Yi; Zhu, Weiming; Li, Ning; Li, Jieshou
texts
eye 36
favorite 0
comment 0
This article is from PLoS ONE , volume 8 . Abstract Objective: Inflammatory bowel disease (IBD) is commonly treated with thiopurines such as azathioprine and mercaptopurine for the maintenance of remission. Studies examining chemopreventive of these medications on colorectal neoplasm in IBD patients have yielded conflicting results. We performed a meta-analysis to assess the role of thiopurines for this indication. Methods: We performed a systematic search of PubMed, Web of Science, EMBASE and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842949
